Peyronie’s Disease Treatment

Peyronie's disease is a medical condition characterized by the formation of fibrous scar tissue within the penile shaft. It results in the emergence of a distinct plaque known as a Peyronie's plaque. This plaque can induce a curve or bending of the erect penis, causing discomfort during sexual intercourse and potentially compromising sexual activity. 

Peyronie's Disease Peyronie's Disease

Peyronie's Disease Stages

Peyronie's disease progresses through two distinct phases: the acute stage and the chronic stage.

  • Acute Peyronie's disease

This initial stage typically spans six to twelve months. During this phase, a fibrous scar develops beneath the penile skin, leading to a deformation or alteration in shape. Pain may accompany erections or when the penis is flaccid.

  • Chronic Peyronie's disease

In the chronic phase, the scar ceases to grow, and the curvature stabilizes without worsening. Pain often subsides during this stage, although it may persist, especially during erections. Additionally, this phase may be associated with the onset of erectile dysfunction (ED).

Peyronie's Disease: The Cause

The precise origins of Peyronie's disease remain unclear, though it is believed to be linked to trauma or harm inflicted upon the penis. Such injuries can instigate the accumulation of fibrous tissue, also known as collagen, within the penile shaft. Over time, this fibrous tissue undergoes hardening, culminating in plaque formation.

  • Development

The genesis of a Peyronie's plaque begins with minor injuries or trauma sustained by the penis. These injuries can arise during sexual intercourse or result from physical activities like sports or exercise. This trauma leads to minuscule tears within the tunica albuginea, a fibrous layer enveloping the cavernosal bodies of the penis.

In response to these injuries, the body produces collagen to repair the tears. However, rather than healing uniformly, collagen accumulates in a localized area, giving rise to a rigid, fibrous plaque. These plaques can exhibit a broad spectrum of sizes, ranging from inconspicuously small to significantly impactful.

As the plaque continues to evolve, it possesses the potential to induce bending or curving of the penis during erections. Such deviations can result in discomfort during sexual activity and sexual function implications. In severe instances, the plaque can even lead to penile shortening or distortion.

Diagnosis of Peyronie's Disease

The identification of Peyronie's disease needs a comprehensive assessment involving a physical examination, medical history evaluation, and prevailing symptom assessment. Additionally, Ultrasound or MRI scans can diagnose penile plaque formation.

Though numerous therapeutic options exist for Peyronie's disease, the utilization of medications for its treatment remains a subject of ongoing discussion.

Medication for Peyronie's Disease

  • What Works

Scientific substantiation for the utility of specific medications in managing Peyronie's disease is somewhat limited. Presently, the sole FDA-approved medication for Peyronie's disease is Xiaflex. It uses an enzyme to dismantle the scar tissue within the penile region.

Pentoxifylline, on the other hand, has undergone examination due to its potential to Ameliorate blood circulation and mitigate inflammation, rendering it a plausible treatment avenue for Peyronie's disease. Nevertheless, the effectiveness of pentoxifylline in the latest treatment of Peyronie's disease remains constrained according to various studies, some of which indicate minimal improvements in curvature when compared to a placebo.

In contrast to alternative Peyronie treatment, pentoxifylline exhibits reduced efficacy. Notably, surgical interventions like plaque excision or grafting have demonstrated superior outcomes in rectifying penile curvature compared to non-surgical alternatives like pentoxifylline.

It is essential to emphasize that treatment for such a disease is profoundly personalized. It is reliant upon the condition's severity and Peyronie's disease treatment cost. The preferences of both the patient and the attending physician play a vital role. 

  • What Doesn't Work

Despite the limited scientific substantiation regarding the efficacy of certain medications for Peyronie's disease, there is a false side to it. A range of Peyronie's disease treatments, supplements, and medications are frequently promoted as remedies for this condition. Regrettably, these drugs and supplements do not offer effective relief from Peyronie's disease, and in some instances, they may even pose potential risks.

Examples of medications and supplements that have demonstrated ineffectiveness in Peyronie's disease management include:

  • Vitamin E
  • Potaba
  • Collagenase
  • L-Arginine
  • Propionyl-L-carnitine

It is crucial to discuss with your healthcare provider regarding the medications and supplements you may be taking. Equally important is the subtle evaluation of potential advantages and drawbacks associated with these treatments before their use.

Treatment of Peyronie's Disease

There are numerous Peyronie's disease treatment possibilities circling non-surgical and surgical interventions. The selection of the appropriate treatment hinges upon factors such as the gravity of the condition, the prevailing symptoms, and the individual's overall health.

  • Xiaflex

Xiaflex represents a non-surgical avenue for Peyronie's disease treatment, employing an enzyme to dissolve the scar tissue within the penile region. This therapeutic regimen, known for Xiaflex sustained results, typically necessitates multiple injections administered over a period conducted in a medical office.

  • Nesbit Plication

Nesbit plication is a surgical procedure entailing the creation of small incisions in the penis to excise the plaque and rectify penile curvature.

  • Resection and Graft Techniques

Resection and graft techniques involve the removal of the plaque, with subsequent replacement using tissue either harvested from another part of the body or sourced from an external vendor. This approach, along with attempts to dissolve Peyronie's plaque, is typically reserved for severe Peyronie's disease cases.

  • Penile Prosthesis

A penile prosthesis constitutes a surgically implanted device designed to enhance sexual function and align the penis correctly. This option is mostly for severe Peyronie's disease cases in which prior treatments have proven ineffective.

It is of paramount importance to engage in a comprehensive discussion with your healthcare provider, meticulously weighing the advantages and drawbacks of each treatment before arriving at a decision. With appropriate treatment, the majority of individuals affected by Peyronie's disease can alleviate their symptoms and enhance their sexual function.

A Special Note from SMIU

Peyronie's disease is common. Many men experience it at any age. If you have symptoms related to it or any other urological condition, SMIU is here for you.

  • Get tailored care for each patient.
  • Expect personalized services crafted to meet unique needs.
  • Our patients take center stage in our priorities.
  • Anticipate an exceptional medical experience of the highest quality.
  • We nurture a compassionate and health-oriented environment.
  • Envision widespread wellness support.
  • Our qualified team members bring years of proficient mastery to the table.

Frequently Asked Questions

1. Is Peyronie's disease harmless?

Peyronie's disease is not usually considered harmful. However, it can lead to symptoms like penile curvature, pain during erections, and potential erectile dysfunction. These can impact one's quality of life. While it may not be life-threatening, it can certainly affect sexual function and emotional well-being.

2. Who gets affected by Peyronie's disease?

Peyronie's disease can affect men of all ages, but it is more commonly observed in middle-aged and older men. However, it can occur in younger men as well. The exact cause is not known, but factors like genetics, trauma, or underlying health conditions may contribute to its development.

3. Does Peyronie’s disease cause erectile dysfunction?

Peyronie's disease can lead to erectile dysfunction (ED) in some cases. The curvature and scarring of the penis may make it difficult to achieve or maintain an erection suitable for sexual intercourse. The degree of ED can vary depending on the severity of the condition.

4. Does Peyronie’s disease affect size of your penis?

Peyronie's disease can result in penile shortening or a perceived reduction in penis size, particularly in cases with significant curvature or plaque formation. This change in size is due to the bending or curving of the penis caused by the fibrous plaques.

5. How much length can you lose due to Peyronie's disease?

The extent of penile length loss due to Peyronie's disease varies from person to person and is linked to the severity of the condition. Some individuals may experience minimal length loss, while others may notice a more significant reduction in penis size. It is essential to consult with a healthcare provider for an accurate assessment.

6. Will Peyronie’s disease keep me from having sex?

Peyronie's disease can make sexual intercourse more challenging and, in some cases, painful. However, its impact on sexual activity varies among individuals. Many people with Peyronie's disease can still engage in sexual activity with the help of treatments or adjustments to accommodate the curvature or changes in the penis. Consulting with a healthcare provider can help deal with these challenges.



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